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mavacamten will reduce the level or result of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Progestin and ethinyl estradiol are CYP3A4 substrates. Mavacamten may perhaps lessen systemic exposures of ethinyl estradiol and progestin, which can result in contraceptive failure or an i